Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (25): 3693-3698.doi: 10.3969/j.issn.2095-4344.2016.25.007

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 Different bone graft fusion materials applied in lumbar interbody fusion

Qin Jian-pu, Wang Chong, Zhang Peng-yun, Cao Guang-ru, Cai Yu-qiang, Liao Wen-bo   

  1. Department of Spine Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
  • Received:2016-04-26 Online:2016-06-17 Published:2016-06-17
  • Contact: Cao Guang-ru, Master, Associate chief physician, Department of Spine Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
  • About author:Qin Jian-pu, Master, Attending physician, Department of Spine Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China Wang Chong, Master, Attending physician, Department of Spine Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China Qin Jian-pu and Wang Chong contributed equally to this work.
  • Supported by:

    the Science and Technology Foundation of Guizhou Provincial Health Department, China, No. gzwki2013-1-011

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Abstract:

BACKGROUND: The choice of suitable bone graft substitute is vital for spinal fusion treatment, which can solve some limitations caused by autogenous bone graft and other materials.

 
OBJECTIVE: To investigate properties of different bone graft fusion materials, and to explore their application in dog spinal fusion of lumbar vertebral body.
METHODS: Forty-five Chinese rural dogs were enrolled to prepare lumbar interbody fusion models, and then were randomized into three groups transplanted with autogenous ilium, recombinant human bone morphogenetic protein-2 composite or allograft ilium, respectively. Afterwards, effects of different materials in the lumbar interbody fusion were analyzed.

RESULTS AND CONCLUSION: The fusion rate of the composite group was significantly higher than those of the other groups (P < 0.05). Oswestry dysfunction index of the composite group was significantly lower than those of the other groups after surgery (P < 0.05). Hematoxylin-eosin staining showed that dogs achieved complete bony fusion, continuous bone trabecula gradually formed, and there was no gap between the transplanted bone and the bone surface in the composite group compared with the other groups at 12 weeks after surgery. These results demonstrate that recombinant human bone morphogenetic protein-2 composites can significantly promote the spinal fusion superior to autologous and allogeneic bone grafts.

 

 

 

Key words: Tissue Engineering, Biocompatible Materials, Spine, Bone Transplantation, Biomechanics

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